High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. – Cost Effective Supplements

High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial.

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Link to full study

http://www.ncbi.nlm.nih.gov/pubmed/18984840

Conclusion of this study

A 50% or greater reduction in headaches was seen in 14/21 patients in the placebo group and 12/27 patients in the riboflavin group (not significant P = .125). There were no differences between riboflavin and placebo for primary or secondary outcome variables. These results suggest that riboflavin is not an effective therapy for preventing migraine in children. A high placebo responder rate was seen, with implications for other studies of migraine in children.