Inositol addition does not improve depression in SSRI treatment failures.
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Link to full study
http://www.ncbi.nlm.nih.gov/pubmed/10907738
Conclusion of this study
Some antidepressants, such as Lithium, can augment the antidepressant effect of serotonin selective uptake inhibitors (SSRI) in patients who have failed to respond to SSRI. Inositol has demonstrated antidepressant effects but in a controlled double blind augmentation trial did not improve depression in SSRI treatment failures.
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