The role of cystine-glutamate exchange in nicotine dependence in rats and humans.
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Link to full study
http://www.ncbi.nlm.nih.gov/pubmed/19103434
Conclusion of this study
These results indicate that the cystine-glutamate exchanger and the glial glutamate transporter are downregulated after nicotine self-administration, and augmenting exchanger activity with N-acetylcysteine reduced the number of cigarettes smoked in nicotine-dependent individuals.
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