Double-blind, controlled trial of inositol treatment of depression.
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Link to full study
http://www.ncbi.nlm.nih.gov/pubmed/7726322
Conclusion of this study
This may be the first use of the precursor strategy for a second messenger rather than a neurotransmitter in treating depression. Although inositol had a significant antidepressant effect in this study, replication is crucial.
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