Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation.
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Link to full study
http://www.ncbi.nlm.nih.gov/pubmed/11985880
Conclusion of this study
Using double-blind placebo-controlled paradigm, we demonstrated that dietary supplement of creatine (8 g/day for 5 days) reduces mental fatigue when subjects repeatedly perform a simple mathematical calculation. After taking the creatine supplement, task-evoked increase of cerebral oxygenated hemoglobin in the brains of subjects measured by near infrared spectroscopy was significantly reduced, which is compatible with increased oxygen utilization in the brain.
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