Zinc supplementation augments efficacy of imipramine in treatment resistant patients: a double blind, placebo-controlled study. – Cost Effective Supplements

Zinc supplementation augments efficacy of imipramine in treatment resistant patients: a double blind, placebo-controlled study.

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Link to full study

http://www.ncbi.nlm.nih.gov/pubmed/19278731

Conclusion of this study

Zinc supplementation augments the efficacy and speed of onset of therapeutic response to imipramine treatment, particularly in patients previously nonresponsive to antidepressant pharmacotherapies. These data suggest the participation of disturbed zinc/glutamatergic transmission in the pathophysiology of drug resistance.