Effectiveness of chromium in atypical depression: a placebo-controlled trial.
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Link to full study
http://www.ncbi.nlm.nih.gov/pubmed/12559660
Conclusion of this study
Chromium picolinate shows promising antidepressant effects in atypical depression. Its mechanism of action may relate to 5HT2A downregulation, increased insulin sensitivity, or to other effects.
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