Use of Vitex agnus-castus in migrainous women with premenstrual syndrome: an open-label clinical observation.
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Link to full study
http://www.ncbi.nlm.nih.gov/pubmed/22791378
Conclusion of this study
Concerning migraine, 42 % of patients experienced a reduction higher than 50 % in frequency of monthly attacks, and 57 % of patients experienced a reduction higher than 50 % in monthly days with headache. No patients reported remarkable side effects. Pending a placebo-controlled trial to confirm our results, we observed that the use of VAC in migrainous women affected by PMS resulted to be safe and well tolerated, and may positively influence the frequency and duration of migraine attacks.
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