Thermotolerance and heat acclimation may share a common mechanism in humans.
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Link to full study
http://www.ncbi.nlm.nih.gov/pubmed/21613575
Conclusion of this study
Consistent with the concept that thermotolerance and heat acclimation are related through the heat shock response, repeated exercise/heat stress increases cytoprotective HSP70 and reduces circulating cytokines, contributing to reductions in cellular and systemic markers of heat strain. Exercising under a heat shock response-inhibitor prevents both cellular and systemic heat adaptations.
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