A significant 40% reduction in ACF number occurred with the 4-g dose (P < 0.005), whereas ACF were not reduced in the 2-g group. The ACF reduction in the 4-g group was associated with a significant, five-fold increase in posttreatment plasma curcumin/conjugate levels (versus pretreatment; P = 0.009). Curcumin was well tolerated at both 2 g and 4 g. Our data suggest that curcumin can decrease ACF number, and this is potentially mediated by curcumin conjugates delivered systemically.

Curcumin

Health conditions analyzed in this study

Colorectal Cancer

1 supplement Slightly Positive Curcumin

Functions related to this study

Digestion

1 supplement Slightly Positive Curcumin

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Body systems related to this study

Digestive System

1 supplement Curcumin