Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials.
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Link to full study
http://www.ncbi.nlm.nih.gov/pubmed/24299602
Conclusion of this study
Findings from clinical trials conducted to date indicate that saffron supplementation can improve symptoms of depression in adults with MDD. Larger clinical trials, conducted by research teams outside of Iran, with long-term follow-ups are needed before firm conclusions can be made regarding saffron's efficacy and safety for treating depressive symptoms.
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