Creatine monohydrate in ALS: effects on strength, fatigue, respiratory status and ALSFRS.
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Link to full study
http://www.ncbi.nlm.nih.gov/pubmed/18608103
Conclusion of this study
In conclusion, creatine monohydrate (5 g/d) did not have an obvious benefit on the multiple markers of disease progression measured over nine months. We measured fatigue during isometric contraction and found no significant improvement despite anecdotal patient reports prior to and during the study. The trend toward improved survival was also found in another recently completed blinded trial using creatine monohydrate. Further investigation on the possible survival benefit of creatine in this patient population is ongoing.
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