In contrast, vitamin C supplementation decreased urinary concentrations of DHN-MA (three-way interaction p=0.0304) in nonsmoking men compared with nonsmoking women (p<0.05), as well as in nonsmoking men compared with smoking men (p<0.05). Vitamin C supplementation also decreased (p=0.0092) urinary total of metabolites by ~20%. Thus, HPNE metabolites can be reduced favorably in response to improved plasma ascorbic acid concentrations, an effect due to ascorbic acid antioxidant function.

Vitamin C

Health conditions analyzed in this study

Oxidative Damage

1 supplement Slightly Positive Vitamin C

Functions related to this study

Antioxidant potential

1 supplement Slightly Positive Vitamin C

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Body systems related to this study

Overall Systems

1 supplement Vitamin C