In the dose-ranging study there was a linear trend between the dosage of vitamin E and percentage reduction in plasma F2-isoprostane concentrations which reached significance at doses of 1600 IU (35+/-2%, p<0.035) and 3200 IU (49+/-10%, p<0.005). This study provides information on the dosage of vitamin E that decreases systemic oxidant stress in vivo in humans and informs the planning and evaluation of clinical studies that assess the efficacy of vitamin E to mitigate disease.

Vitamin E

Health conditions analyzed in this study

Oxidative Damage

2 supplements Slightly Positive Vitamin E Slightly Positive Vitamin E

Functions related to this study

Antioxidant potential

1 supplement Slightly Positive Vitamin E

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Body systems related to this study

Overall Systems

1 supplement Vitamin E