Vitamin D threshold to prevent aromatase inhibitor-induced arthralgia: a prospective cohort study. – Cost Effective Supplements

Vitamin D threshold to prevent aromatase inhibitor-induced arthralgia: a prospective cohort study.

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Link to full study

http://www.ncbi.nlm.nih.gov/pubmed/20665105

Conclusion of this study

In the whole cohort, there was an increase in joint pain (mean 1.16 points SD 2.66; P < 0.001) and the increase was significantly (P = 0.02) attenuated in those that reached concentrations of 25(OH)D of ≥40 ng/ml, with a lower risk of incident arthralgia (OR 0.12 ** [0.03 to 0.40]). A target concentration of 40 ng/ml 25OHD may prevent development of AI arthralgia but higher loading doses are required to attain this level in women with deficiency at baseline.