Mitochondrial DNA haplogroups influence the therapeutic response to riboflavin in migraineurs. – Cost Effective Supplements

Mitochondrial DNA haplogroups influence the therapeutic response to riboflavin in migraineurs.

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Link to full study

http://www.ncbi.nlm.nih.gov/pubmed/19414726

Conclusion of this study

In this pharmacogenetic study, riboflavin appears to be more effective in patients with migraine with non-H mitochondrial DNA haplotypes. The underlying mechanisms are unknown, but could be related to the association of haplogroup H with increased activity in complex I, which is a major target for riboflavin. Our results may have ethnic implications, since haplogroup H is chiefly found in the European population.