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Grape Seed Extract

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What are Grape Seed Extract's other names?

  • GSE
  • Oligomeric Procyanidins
  • OPC-3
  • Procyanidin

What is Grape Seed Extract's recommended dosage?

  • Recommended daily intake: 150 - 300 mg

What supplements interact with Grape Seed Extract?

  • Grape Seed Extract and Jiaogulan

  • Grape Seed Extract and Pterostilbene


What can Grape Seed Extract help with?

  • Grape Seed Extract for Edema

  • Grape Seed Extract for Melasma

  • Grape Seed Extract for Oxidative Damage


What is Grape Seed Extract used for?

  • Grape Seed Extract for Heart health

test
Moderately Positive


Collectively, these results suggest that flavanol-rich products, such as cocoa, wine, grape seed, or tea can provide a dietary means by which to augment vascular function in at-risk populations.


test
Moderately Positive


GSE alone improved flow-mediated dilatation determined ultrasonically by an absolute $1.1$ % compared with control. There was no effect of the combination of GSE with quercetin. No other blood or urine measure was altered. Thus sufficient polyphenols from GSE appear to be absorbed to influence endothelial nitric oxide production, and GSE has the potential to favourably influence vascular function.


test
Slightly Positive


Blood pressure was recorded using an ambulatory monitoring device at the start of the treatment period and at the end. Both the systolic and diastolic blood pressures were lowered after treatment with GSE as compared with placebo. There were no significant changes in serum lipids or blood glucose values. These findings suggest that GSE could be used as a nutraceutical in a lifestyle modification program for patients with the metabolic syndrome.


test
Slightly Positive


Egger's weighted regression statistic suggested low likelihood of publication bias in all analysis (P>0.05 for all), except for the effect on diastolic blood pressure (P=0.046). Based on the currently available literature, grape seed extract appears to significantly lower systolic blood pressure and heart rate, with no effect on lipid or CRP levels. Larger randomized, double-blinded trials evaluating different dosages of grape seed extract and for longer follow-up durations are needed.


test
Slightly Positive


GSE significantly improved markers of inflammation and glycaemia and a sole marker of oxidative stress in obese Type 2 diabetic subjects at high risk of cardiovascular events over a 4-week period, which suggests it may have a therapeutic role in decreasing cardiovascular risk.


test
Slightly Positive


The antioxidant potential of grape seed extract polyphenols may prove effective in a model of oxidative stress (smoking); however more investigational data are needed before use in wider clinical settings.


test
Slightly Positive


The intake of GSE is a contributing factor in the inhibition of leg swelling in healthy women during prolonged sitting.


  • Grape Seed Extract for Weight loss

  • Grape Seed Extract for Skin, hair and nails

  • Grape Seed Extract for Antioxidant potential


What are Grape Seed Extract's effects on the body?

  • Grape Seed Extract for the Cardiovascular System

Collectively, these results suggest that flavanol-rich products, such as cocoa, wine, grape seed, or tea can provide a dietary means by which to augment vascular function in at-risk populations.


GSE alone improved flow-mediated dilatation determined ultrasonically by an absolute $1.1$ % compared with control. There was no effect of the combination of GSE with quercetin. No other blood or urine measure was altered. Thus sufficient polyphenols from GSE appear to be absorbed to influence endothelial nitric oxide production, and GSE has the potential to favourably influence vascular function.


Blood pressure was recorded using an ambulatory monitoring device at the start of the treatment period and at the end. Both the systolic and diastolic blood pressures were lowered after treatment with GSE as compared with placebo. There were no significant changes in serum lipids or blood glucose values. These findings suggest that GSE could be used as a nutraceutical in a lifestyle modification program for patients with the metabolic syndrome.


Egger's weighted regression statistic suggested low likelihood of publication bias in all analysis (P>0.05 for all), except for the effect on diastolic blood pressure (P=0.046). Based on the currently available literature, grape seed extract appears to significantly lower systolic blood pressure and heart rate, with no effect on lipid or CRP levels. Larger randomized, double-blinded trials evaluating different dosages of grape seed extract and for longer follow-up durations are needed.


GSE significantly improved markers of inflammation and glycaemia and a sole marker of oxidative stress in obese Type 2 diabetic subjects at high risk of cardiovascular events over a 4-week period, which suggests it may have a therapeutic role in decreasing cardiovascular risk.


The antioxidant potential of grape seed extract polyphenols may prove effective in a model of oxidative stress (smoking); however more investigational data are needed before use in wider clinical settings.


The intake of GSE is a contributing factor in the inhibition of leg swelling in healthy women during prolonged sitting.


  • Grape Seed Extract for the Overall Systems

  • Grape Seed Extract for the Integumentary system

  • Grape Seed Extract for the Digestive System

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