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SAME

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What are SAME's other names?

  • Ademethionine
  • Adomet
  • S-Adenosyl Methionine
  • S-adenosyl-L-methionine

What is SAME's recommended dosage?

  • Recommended daily intake: 600 - 1200 mg
  • Recommended daily doses: 2 - 3

What supplements interact with SAME?

No supplements that have a synergystic effect with this one.

What can SAME help with?

  • SAME for Depression

  • SAME for Osteoarthritis

  • SAME for Pain

  • SAME for Cholestasis

  • SAME for Viral Infections


What is SAME used for?

  • SAME for Joint support

  • SAME for Overall health

  • SAME for Emotional health

  • SAME for Immunity

  • SAME for Detox

  • SAME for Mental health


What are SAME's effects on the body?

  • SAME for the Skeletal System

  • SAME for the Nervous System

One patient experienced mild nausea, and another two patients developed mild diarrhea, which resolved spontaneously. The mean HDS score before treatment was 27.09 +/- 6.04 (mean +/- standard deviation) and was 9.55 +/- 7.29 after SAM treatment (p < 0.0001). Although uncontrolled and preliminary, this study suggests that SAM is well tolerated and may be a safe and effective alternative to the antidepressant agents currently used in patients with Parkinson's disease.


SAMe administered orally at a dose of 1,200 mg daily was shown to exert the same analgesic activity as naproxen at a dose of 750 mg daily. Both drugs were more effective than placebo (p less than 0.01).


SAMe has a slower onset of action but is as effective as celecoxib in the management of symptoms of knee osteoarthritis. Longer studies are needed to evaluate the long-term effectiveness of SAMe and the optimal dose to be used.


These preliminary results provide encouraging evidence for the use of SAMe in the treatment of MDD. Histamine and carnitine serum level may not necessarily moderate response to SAMe.


These preliminary results suggest that SAMe can be an effective, well-tolerated, and safe adjunctive treatment strategy for SRI nonresponders with major depressive disorder and warrant replication.


SAMe appears to be as effective as NSAIDs in reducing pain and improving functional limitation in patients with OA without the adverse effects often associated with NSAID therapies.


These preliminary data suggest that SAMe can improve memory-related cognitive symptoms in depressed patients, and warrant replication.


Psychometric tests concerning noopsychic and thymopsychic measures as well as critical flicker fusion frequency generally demonstrated a lack of differences between SAMe and placebo, which reflects a good tolerability of the drug in elderly subjects. This was corroborated by the findings on side effects, pulse and blood pressure.


  • SAME for the Digestive System

  • SAME for the Immune System

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