SNP-stimulated vasodilation was similar before and after 2 weeks of treatment in the control and Pycnogenol groups. The administration of N(G)-monomethyl-L-arginine, an NO synthase inhibitor, completely abolished Pycnogenol-induced augmentation of the FBF response to ACh. These findings suggest that Pycnogenol augments endothelium-dependent vasodilation by increasing in NO production. Pycnogenol would be useful for treating various diseases whose pathogeneses involve endothelial dysfunction.

Pycnogenol

Health conditions analyzed in this study

Functions related to this study

Heart health

1 supplement Moderately Positive Pycnogenol

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Body systems related to this study

Cardiovascular System

1 supplement Pycnogenol