Melatonin responses to clonidine and yohimbine challenges. – Cost Effective Supplements

Melatonin responses to clonidine and yohimbine challenges.

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Link to full study

http://www.ncbi.nlm.nih.gov/pubmed/7647083

Conclusion of this study

Yohimbine ingestion produced significant rises in pulse rate and the urge to urinate compared to placebo. Both doses of clonidine resulted in a significant reduction in pulse rate, systolic and diastolic blood pressure, and significant increases in drowsiness and other measures of sedation following ingestion. Only clonidine 300 micrograms produced a significant elevation in GH release. This study highlights the limitations of oral neuroendocrine challenge studies.