Lactobacillus Rhamnosus for OCD and ADHD Treatment?


Table of Contents

Can Lactobacillus Rhamnosus be effective in OCD treatment?

Lactobacillus Rhamnosus can be effective in OCD treatment by positively reinforcing the action of GABA neurotransmitter which functions in calming down the central nervous system and reducing anxiety, fear, and depression. A study has shown that lactobacillus rhamnosus reduced OCD-like behavior in lab mice owing to their gut-brain connection.

Other clinical trial studies are still underway to determine their efficacy and safety in the human population.

Additionally, a 2020 clinical study done on humans, revealed that lactobacillus rhamnosus probiotic supplementation showed great improvements in protecting and maintaining cognitive function in the elderly.

Is Lactobacillus Rhamnosus good for ADHD?

Lactobacillus Rhamnosus is good for ADHD because it helps to regulate serotonin levels by improving gut health. This was revealed in a study conducted on children with ADHD who were treated with lactobacillus Rhamnosus supplements and reported back better health-related quality of life.

Similarly, another study conducted on 75 infants who were followed up for 13 years has shown that lactobacillus rhamnosus supplementation early on in life can have major preventative effects on neuropsychiatric disorders like ADHD by affecting many pathways including the gut microbiota.

In the video below, Dr. Ruscio talks about how a recent study has provided conclusive proof that probiotics help with depression:

This is our recommended Probiotic Supplement with Lactobacillus Rhamnosus:


Biotics 8 – Probiotic Formula For Overall Gut Health

What are the benefits of Lactobacillus Rhamnosus for Depression?

The benefits of Lactobacillus Rhamnosus for depression remain in its antidepressive effects which proved to be superior to other psychiatric medications due to its minimal side effects and considerable safety. In fact, using lactobacillus rhamnosus supplements in treating postpartum depression in a study on breastfeeding women turned out to be very effective in improving their mood and lowering their anxiety levels.

Another recent study in 2020, reveals the potential of lactobacillus rhamnosus and other probiotics in reducing depression because of its association with the gut-brain axis which plays a critical role in mood regulation.

What are the effects of Lactobacillus Rhamnosus on the Vagus Nerve?

Lactobacillus Rhamnosus can help the Vagus Nerve to regulate GABA neurotransmitter levels, this aids in reducing stress levels and inducing positive effects.

A study published in the Journal of Proceedings of the National Academy of Sciences in the United States of America in 2011, proved that treatment with lactobacillus rhamnosus in lab mice had positive effects in reducing stress, anxiety, and depression and is linked to modulating the gut-brain axis with the vagus nerve. 

Similarly, another study in 2012, reiterates the potential of lactobacillus rhamnosus as a potential therapeutic alternative in psychiatric conditions.

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This article makes use of information from the U.S. National Library of Medicine under the terms of the Creative Commons Attribution 4.0 International License.

  1. Kantak PA, Bobrow DN, Nyby JG. Obsessive-compulsive-like behaviors in house mice are attenuated by a probiotic (Lactobacillus rhamnosus GG). Behav Pharmacol. 2014 Feb;25(1):71-9. DOI: 10.1097/FBP.0000000000000013. PMID: 24257436.
  2. Sanborn V, Azcarate-Peril MA, Updegraff J, Manderino L, Gunstad J. Randomized Clinical Trial Examining the Impact of Lactobacillus rhamnosus GG Probiotic Supplementation on Cognitive Functioning in Middle-aged and Older Adults. Neuropsychiatr Dis Treat. 2020 Nov 13;16:2765-2777. DOI: 10.2147/NDT.S270035. PMID: 33223831; PMCID: PMC7671471.
  3. Kumperscak HG, Gricar A, Ülen I, Micetic-Turk D. A Pilot Randomized Control Trial With the Probiotic Strain Lactobacillus rhamnosus GG (LGG) in ADHD: Children and Adolescents Report Better Health-Related Quality of Life. Front Psychiatry. 2020 Mar 17;11:181. DOI: 10.3389/fpsyt.2020.00181. PMID: 32256407; PMCID: PMC7092625.
  4. Pärtty, A., Kalliomäki, M., Wacklin, P. et al. A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial. Pediatr Res 77, 823–828 (2015).
  5. Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16050-5. DOI: 10.1073/pnas.1102999108. Epub 2011 Aug 29. PMID: 21876150; PMCID: PMC3179073.
  6. Perez-Burgos A, Wang B, Mao YK, Mistry B, McVey Neufeld KA, Bienenstock J, Kunze W. Psychoactive bacteria Lactobacillus rhamnosus (JB-1) elicits rapid frequency facilitation in vagal afferents. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 15;304(2):G211-20. DOI: 10.1152/ajpgi.00128.2012. Epub 2012 Nov 8. PMID: 23139216.
  7. Yong SJ, Tong T, Chew J, Lim WL. Antidepressive Mechanisms of Probiotics and Their Therapeutic Potential. Front Neurosci. 2020 Jan 14;13:1361. DOI: 10.3389/fnins.2019.01361. PMID: 32009871; PMCID: PMC6971226.
  8. Slykerman RF, Hood F, Wickens K, Thompson JMD, Barthow C, Murphy R, Kang J, Rowden J, Stone P, Crane J, Stanley T, Abels P, Purdie G, Maude R, Mitchell EA; Probiotic in Pregnancy Study Group. Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomised Double-blind Placebo-controlled Trial. EBioMedicine. 2017 Oct;24:159-165. DOI: 10.1016/j.ebiom.2017.09.013. Epub 2017 Sep 14. PMID: 28943228; PMCID: PMC5652021.
  9. Tette FM, Kwofie SK, Wilson MD. Therapeutic Anti-Depressant Potential of Microbial GABA Produced by <i>Lactobacillus rhamnosus</i> Strains for GABAergic Signaling Restoration and Inhibition of Addiction-Induced HPA Axis Hyperactivity. Current Issues in Molecular Biology. 2022 Mar;44(4):1434-1451. DOI: 10.3390/cimb44040096. PMID: 35723354; PMCID: PMC9164062.
Lactobacillus Rhamnosus for OCD and ADHD Treatment?
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