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What are Alpha-Lipoic Acid's other names?

• 1, 2-dithiolane-3-pentanoic acid
• ALA
• Thioctic acid
• Tiolepta

What is Alpha-Lipoic Acid's recommended dosage?

• Recommended daily intake: 300 - 600 mg

What supplements interact with Alpha-Lipoic Acid?

Alpha-Lipoic Acid and Coenzyme Q10

1 synergy Decrease of Cardiovascular Disease Risk

Alpha-Lipoic Acid and Creatine

1 synergy Increase of Effectiveness

Alpha-Lipoic Acid and L-Carnitine

1 synergy Increase of Antioxidant Potential

Alpha-Lipoic Acid and Melatonin

1 synergy Increase of Antioxidant Potential

Alpha-Lipoic Acid and Vitamin E

1 synergy Increase of Antioxidant Potential

What can Alpha-Lipoic Acid help with?

Alpha-Lipoic Acid for Diabetic Nerve Problems

2 studies Moderately Positive Based on these results, ALA should be considered as a treatment option for patients with PDN. When discussing supplementation with patients, it is important to discuss potential side effects; vitamin, mineral, and drug interactions; and current evidence available regarding efficacy. Moderately Positive Four-year treatment with ALA in mild-to-moderate DSPN did not influence the primary composite end point but resulted in a clinically meaningful improvement and prevention of progression of neuropathic impairments and was well tolerated. Because the primary composite end point did not deteriorate significantly in placebo-treated subjects, secondary prevention of its progression by ALA according to the trial design was not feasible.

Alpha-Lipoic Acid for Intermittent Claudication

1 study Moderately Positive LA may confer pain relief during exercise. However, longer and larger trials are warranted to determine long-term effects of LA alone or combined with other interventions on PAD symptoms.

Alpha-Lipoic Acid for Inflammation

2 studies Slightly Positive Administration of irbesartan and/or lipoic acid to patients with the metabolic syndrome improves endothelial function and reduces proinflammatory markers, factors that are implicated in the pathogenesis of atherosclerosis. Slightly Positive Dietary supplementation of antioxidants at 900 mg/day for 4 weeks did not change the blood biomarkers of inflammation and disease severity of RA patients under conventional medical treatments. Further considerations for dose-response relationships, duration of supplementation, and susceptible biomarkers are required.

Alpha-Lipoic Acid for Oxidative Damage

6 studies Slightly Positive ALA supplementation significantly reduced hsCRP levels, which is a risk factor for cardiovascular disease in HD patients. Slightly Positive However, when α-lipoic acid is combined with exercise, this atherogenic effect is abolished. Slightly Positive It is concluded that alpha-lipoic acid supplementation diminishes oxidative damage. It does not abolish differences in glutathione antioxidant system between untrained and trained subjects but modulates a pro-antioxidant response to the muscle-damaging exercise. Slightly Positive Our data showed that sHT patients exists impaired endothelial function, and antioxidant alpha-lipoic acid can improve endothelial function, through decrease of oxygen- derived free radicals. Slightly Positive Supplementation with alpha-lipoic acid may positively impact patients with HIV and acquired immune deficiency syndrome by restoring blood total glutathione level and improving functional reactivity of lymphocytes to T-cell mitogens. Slightly Positive Thus the data show that supportive therapy with PL along with the antioxidants hydrosoluble CoQ10, alpha-lipoic acid and vitamin E is an effective way of controlling the complications of type 2 diabetes (Tab. 7, Fig. 2, Ref. 44).

Alpha-Lipoic Acid for Atherosclerosis

1 study Slightly Negative However, when α-lipoic acid is combined with exercise, this atherogenic effect is abolished.

What is Alpha-Lipoic Acid used for?

What are Alpha-Lipoic Acid's effects on the body?