7 proven Kalawalla benefits (Best time to take? Side effects?)

What are Kalawalla’s Benefits?

Kalawalla provides many health benefits:

  • Immune system regulation and support
  • Anti-inflammatory
  • Antioxidant (fights free radicals)
  • Skin cell protection
  • Brain cell protection
  • Blood cleansing

As a natural food supplement, it protects against the following health conditions:

  • Immuno-deficiency
  • Psoriasis
  • Vitiligo
  • Sunlight-induced dermatitis
  • UV radiation sunburns
  • Dementia

What is the best time to take kalawalla?

Since Kalawalla performs its functions better at a lower pH level, the best time to take Kalawalla is 30 minutes before any meal. Also, you can try taking it before bed, about 1-2 hours after the last meal of the day.

What are Kalawalla’s side effects?

Kalawalla side effects may include:

  • slight stomach discomfort
  • indigestion
  • skin itchiness
  • sedation
  • low blood pressure
  • rapid heart rate

Symptoms usually go away after taking Kalawalla for a short time.

What is a Kalawalla Plant?

Kalawalla (brand name) is a herbal extract from the Polypodium Leucotomos fern plant, which grows only in the South American rainforest. The name of the plant comes from the dense scales that cover the rhizome (roots). These herbs belong to the Polypodiaceae family of ferns, which includes around 1650 species.

See below a video of a lecture about Polypodium Leucotomos Extract as a photoprotective and anti aging oral supplement

Kalawalla herb other names

English

  • golden polypody
  • golden serpent fern
  • cabbage palm fern
  • gold-foot fern
  • blue-star fern
  • hare-foot fern
  • rabbit-foot fern
  • Heliocare (brand name)
  • Kalawalla (brand name)
  • fern block

Spanish

  • calaguala
  • calahuala
  • anapsos
  • serpiente dorada
  • helecho palma
  • polipodio de las Antillas
  • polipodio de México
  • hierba del lagarto
  • cotochupa
  • huayhuashi-chupa
  • Mirane
  • Temakaje

Hawaiian

  • laua`e haole

Portuguese

  • samambaia

Swedish

  • hartassbräken

German

  • Calagulawurzel

French

  • Polipode coriace

Dementia

This study was done to evaluate the effects of two doses of anapsos versus placebo on patients with dementia caused by either Alzheimer’s or Vascular disease.

Anapsos-for-Alzheimers

Study Information

  • Title: Double-blind, randomized, placebo-controlled pilot study with anapsos in senile dementia: effects on cognition, brain bioelectrical activity and cerebral hemodynamics.
  • Length: 28 days.

Subject Information

  • Number of Subjects: 45.
  • Age range: 56-89.
  • Mean age: 73.8.
  • Health Status: mild to moderate senile dementia. 22 patients with vascular type dementia and 23 patients with Alzheimer type dementia.

Method used

Patients were divided into 3 groups, and were given the following dosages for 4 weeks:

  • 15 patients treated with placebo
  • 15 patients treated with 360 mg/day of anapsos
  • 15 patients treated with 720 mg/day of anapsos

At the start of the study and after the 4-week period of treatment, the following functions were evaluated:

  • cognitive performance
  • brain electrical activity power
  • blood flow in the middle cerebral arteries

Results

Patients receiving 360 mg/day of anapsos showed a significant improvement in:

  • cognitive performance
  • increased cerebral blood flow in cerebral arteries
  • increase in electrical activity frequencies

Conclusions

The results show that anapsos at 360 mg/day improves

  • cognitive performance
  • cerebral blood flow
  • brain electrical activity

in patients with senile dementia. These effects of anapsos were more significant in patients with mild mental deterioration and/or with dementia of the Alzheimer type.

UV radiation

The protective effect against sunlight with an oral extract of Polypodium leucotomos was investigated in this study.

Study Information

  • Title: Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin.
  • Length: 6 days.

Subject Information

  • Number of Subjects: 9.
  • Health Status: healthy skin types II and III.

Method used

Patients were exposed to artificial UV radiation after oral consumption of Polypodium leucotomos (7.5 mg/kg).

Results

Polypodium leucotomos treated skin showed:

  • significant decrease in redness
  • less sunburn cells
  • less molecular lesions
  • skin cells increased rapidly in numbers.
  • trend towards cell preservation.

Conclusion

Polypodium leucotomos is effective for protection of skin against UV radiation.

Psoriasis

Kalawalla-for-Psoriasis

Study Information

  • Title: Comparative study between 120 mg. of anapsos and a placebo in 37 psoriasis patients.

Subject Information

  • Number of Subjects: 37.
  • Health Status: psoriasis.

Method used

  • 13 patients took placebo
  • 22 patients took 120 mg of Anapsos
  • 2 patients abandoned the treatment

Results

Out of the 22 patients who used anapsos:

  • 9 obtained full whitening
  • 5 got whitenings between 40% and 80%
  • 5 got a maximum whitening of 40%
  • 3 had no results

Conclusions

The absence of side effects, good tolerance of the product, and the number of results make the authors consider anapsos for the treatment of psoriasis.

Sunlight-induced Rash

Idiopathic photodermatoses (IP) are a recurrent, acquired sunlight-induced rash of delayed onset, appearing after exposure to ultraviolet radiation in susceptible individuals.

The aim of this study was to assess the photoprotective activity of polypodium leucotomos (PL) in IP.

Study Information

  • Title: Oral polypodium leucotomos extract photoprotective activity in 57 patients with idiopathic photodermatoses.

Subject Information

  • Number of Subjects: 57.
  • Health Status: 53 patients with polymorphic light eruption, 4 patients with solar urticaria.

Method used

  • UV protection filters were excluded.
  • Patients were exposed to sunlight
  • Patients consumed 480 mg/day of PL extract.

Results

  • 73.68% of the patients had a significant reduction of skin reaction and symptoms.
  • No side effects were observed.

Conclusions

Due to its lack of toxicity and level of protection, PL is an effective and safe treatment for sunlight-induced skin conditions.

Vitiligo

The first choice treatment for vitiligo is therapy with a narrow-band type B ultraviolet light (NB-UVB). This study was done to investigate if kalawalla improves repigmentation (regain on skin color) with NB-UVB.

Kalawalla-for-Vitiligo

Study Information

  • Title: Comparative study between 120 mg. of anapsos and a placebo in 37 psoriasis patients.
  • Duration: 26 weeks.

Subject Information

  • Number of Subjects: 50.
  • Health Status: vitiligo.

Method used

Patients in the kalawalla group received 250 mg oral kalawalla or placebo three times daily, combined with NB-UVB twice a week for 25 to 26 weeks.

Results

Repigmentation in the in the head and neck area:

  • kalawalla group 44%
  • placebo 27%

Small repigmentation increases in the kalawalla group:

  • trunk: 6%
  • extremities: 4%
  • feet: 5%

Increased repigmentation in the head and neck area in patients attending more than 80% of required NB-UVB sessions:

  • kalawalla group: 50%
  • placebo: 19%

Repigmentation in the head and neck area for patients with skin types 2 and 3:

  • kalawalla group: 47%
  • placebo: 21%

Conclusion

There is a clear increase in repigmentation of vitiligo in the head and neck when NB-UVB therapy is combined with oral kalawalla. This effect may be more pronounced in light skin types.

Immunity


The aim of the study was to test the immune system boosting capacity of Anapsos, Polypodium leucotomos extract, in vitro in an attempt to explore how this extract acts from an immunological point of view and thus to identify a common link capable of explaining most of its effects.

Study Information

  • Title: Effect of Anapsos (Polypodium leucotomos extract) on in vitro production of cytokines.
  • Duration: 26 weeks.

Subject Information

  • Number of Subjects: 50.
  • Health Status: vitiligo.

Method used

Polypodium leucotomos rhizomes were harvested in Guatemala and the extract, Anapsos, obtained. Mononuclear cells were obtained by density gradient centrifugation from healthy donors, and stimulated with phytohemagglutinin or Pokeweed with and without Anapsos and with Anapsos alone. Cell proliferation was determined by thymidine incorporation. Cells were also stimulated and the following cytokines determined by ELISA at 0, 12, 24, 48, 72, and 96 h: IL-1 beta, TNF-alpha, IL-2, INF-8, IL-4 and IL-10.

Results

Anapsos, Polypodium leucotomos extract, has a modulating effect on the in vitro production and release of cytokines by peripheral blood mononuclear cells of healthy subjects. At doses effective in vivo, Anapsos can stimulate PBMNc proliferation, delay IL-1 beta secretion and at the same time increase that of IL-2, IL-10, and INF-gamma.

Conclusions

Anapsos may have an antagonistic effect on some of the cytokines released on cell stimulation with LPS and/or PHA, which suggests that this product has a pleiotropic effect on different populations in the immune system.

Want to know more?

Click the links below to access the individual topic pages:

Sources

This article makes use of information from the U.S. National Library of Medicine under the terms of the Creative Commons Attribution 4.0 International License.

  1. Middelkamp-Hup MA, Pathak MA, Parrado C, et al. Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin. J Am Acad Dermatol. 2004;51(6):910-918. doi:10.1016/j.jaad.2004.06.027
  2. https://npgsweb.ars-grin.gov/gringlobal/taxon/taxonomydetail?id=27742
  3. Alvarez XA, Pichel V, Pérez P, Laredo M, Corzo D, Zas R, Fernández-Novoa L, Sempere JM, Díaz J, Cacabelos R. Double-blind, randomized, placebo-controlled pilot study with anapsos in senile dementia: effects on cognition, brain bioelectrical activity and cerebral hemodynamics. Methods Find Exp Clin Pharmacol. 2000 Sep;22(7):585-94. PMID: 11196347.
  4. Del Pino Gamboa J, De Sambricio Guiú F, Colomo Gómez C. Estudio comparativo entre anapsos 120 mg. y un placebo en 37 enfermos de psoriasis [Comparative study between 120 mg. of anapsos and a placebo in 37 psoriasis patients]. Med Cutan Ibero Lat Am. 1982;10(3):203-8. Spanish. PMID: 6759814.
  5. Caccialanza M, Recalcati S, Piccinno R. Oral polypodium leucotomos extract photoprotective activity in 57 patients with idiopathic photodermatoses. G Ital Dermatol Venereol. 2011 Apr;146(2):85-7. PMID: 21505393.
  6. Sempere JM, Rodrigo C, Campos A, Villalba JF, Diaz J. Effect of Anapsos (Polypodium leucotomos extract) on in vitro production of cytokines. Br J Clin Pharmacol. 1997 Jan;43(1):85-9. doi: 10.1111/j.1365-2125.1997.tb00037.x. PMID: 9056057.

7 proven Kalawalla benefits (Best time to take? Side effects?)
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